 | Brain Slice Preparation The brain slice preparation is an important lab methodology, for almost all slice based in vitro experiments such as patch-clamping, in the study of the fundamentals of neurophysiology at the cellular and simple circuit levels. This brain slice preparatio |
| Simple Neuron Model - the HH neuron The Hodgkin–Huxley model is a scientific model that describes how action potentials in neurons are initiated and propagated. It is a set of nonlinear ordinary differential equations that approximates the electrical characteristics of excitable cells suc |
| Patch Clamp Technique The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells s |
| Current Clamp Technique The current clamp technique records the membrane potential by injecting current into a cell through the recording electrode. This technique is used to study how a cell responds when electric current enters a cell; this is important for instance for unders |
| Voltage Clamp Technique The voltage clamp technique allows an experimenter to "clamp" the cell potential at a chosen value. This makes it possible to measure how much ionic current crosses a cell's membrane at any given voltage. |
| Study of Synaptic Transmission (Remote trigger) Synapses are junctions between presynaptic membranes (synaptic knobs) and postsynaptic membranes (receptor surfaces of recipient neurons or effectors) through which information is transmitted from one neuron to another. The goal of this remote-triggered e |
| Measuring Field Potentials Using MEA chips Multielectrode arrays (MEAs) or microelectrode arrays are devices that contain multiple plates or shanks through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry. |
| Understanding the Passive Properties of a Simple Neuron (Remote trigger) The goal of this lab exercise is to generate and study action potential of a neuron using remotely-triggered equipment. Action potential is generated by providing a stimulus (input) and modulated by varying the membrane resistance of the cell. |
| Effects of Ion Channels in Membrane Biophysics (Remote trigger) By varying the stimuli and membrane resistance an action potential can be elicited. This action potential generation is the main goal of this lab. Understanding the effects of Na+ and K+ ions in neuron function is one of the main goals of this lab exercis |
| Effect of Noise on Spiking Neurons (Remote trigger) Effect of noise on spiking neurons (remote trigger) Noise in the neuronal network has significant influence on transmission and integration of signals from other neurons as well as alters the firing activity of neurons in population. In this experiment |
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