Neuron Simulation Virtual Lab (pilot) : Biotechnology and Biomedical Engineering : Amrita Vishwa Vidyapeetham Virtual Lab

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Neuron Simulation Virtual Lab (pilot)

This lab uses a graphical web-based Neuron simulator and models a section of excitable neuronal membrane using the Hodgkin-Huxley equations. Various experiments will deal with the several parameters of Hodgkin-Huxley equations and will model resting and action potentials, voltage and current clamp, pharmacological effects of drugs that block specific channels etc. This lab complements some of the exercises in the Virtual Neurophysiology lab.

	Modeling resting potentials in Neurons This experiment deals with the basic principles behind resting potential, how resting ion channels maintain the resting potential and mathematical models used for studying this mechanism.
	Modeling action potentials This experiment deals with the basic principles behind action potentials or spikes, how ion channels generate action potentials and mathematical models used for studying this mechanism.
	Modeling the delayed rectifier Potassium channels This experiment deals with the basic principles behind potassium ion channels in neurons and their effects on action potentials or spikes, how gating properties regulate channel behavior and influence firing.
	Modeling the sodium ion channel and its effects on neural signaling This experiment deals with the basic principles behind sodium ion channels in neurons and their effects on action potentials or spikes, how gating properties regulate channel behavior and influence firing.
	Current Clamp protocol The current clamp technique records the membrane potential by injecting current into a cell through the recording electrode. This technique is used to study how a cell responds when electric current enters a cell; this is important for instance for unders
	Voltage Clamp Protocol The Voltage clamp has been used as the best biophysical technique for the last few decades. In voltage clamp experiments, control the voltage across the membrane, most of the electrophysiological studies were based on injection of current as stimuli and r
	Understanding Frequency-Current relationship Using current clamp techniques, the electroresponsive behavior of cells are studied by generating a frequency(f)-vs-current(I) plot. This experiment deals with the f-I curve.
	Understanding first spike latency - current relationship Using current clamp, the delay to intiation to first spike can be calculated. In this experiment, we use that as a measure to understand neural behavior.
	Voltage-Current (VI) plot This experiment deals about understanding the nature of ionic current using a voltage-current plot usually called V-I plot. It also investigates the role of linearity in ionic current behavior.
	Effects of pharmacological blockers on action potential This experiment deals with the role of blocking certain ion channels using pharmacological drugs.